1) Treatment of disseminated intravascular coagulation complicated by various diseases;

2) Prevention and treatment of arteriovenous thrombosis and pulmonary embolism, ischemic stroke, unstable angina pectoris (to reduce symptoms and prevent myocardial infarction), dangerous myocardial infarction (to prevent early re-infarction and extension of the infarct area and reduce mortality);

3) As anticoagulant drugs during artificial cardiopulmonary, peritoneal or hemodialysis: as maintenance treatment for thrombolytic therapy;

4) Used to prevent blood coagulation during blood transfusion and blood bank to preserve blood and other external anticoagulant;

5) Heparin also has anti-blood lipid, anti-tumor, anti-recurrent abortion in pregnant women, etc., a variety of medical clinical applications:

New uses discovered in 2020:

1. The practice of front-line clinicians found that 20% of COVID-19 patients would have abnormal coagulation function;

2.2. At the press conference of the joint prevention and control mechanism of The State Council, experts said that the autopsy of the remains of 11 COVID-19 patients showed the formation of thrombosis;

3. Li Taisheng, director of Infection Department of Peking Union Medical College Hospital, pointed out that "the development of pneumonia stage 7-14 days after the onset of the disease is of great significance for the prognosis of patients. It is recommended that patients with high risk factors should be treated with immunoglobulin combined with low molecular weight heparin as early as possible".

Heparin has anticoagulant effect and is used as the basic drug in the treatment of COVID-19 in the United States. Heparin API is listed separately in the tender. The basic demand alone is 45.64 trillion units, and the optional demand is as high as 867.237 units. Basic demand, about the current 1 year use of Europe and the United States; Optional demand, almost the previous 18 years of use in Europe and the United States.

At present, heparin is mainly extracted from porcine small intestinal mucosa and cannot be synthesized chemically. China is rich in hog production and has become the world's largest producer and exporter of heparin. From a global perspective, the United States has a huge amount of strategic heparin API, and the price of heparin API is expected to continue to maintain the upward trend.