1930s, Europe and America, bovine lung/papain/Lice bisulfite sodium/enzymatic hydrolysis

1980s, China, Porcine small intestinal mucosa/saltation/yield: 5000-2500;

In the 1990 s:

(1) China, Porcine small intestinal mucosa/salination + activated pancreatic pulp/yield: 2500 - > 1800;

(2) European and American, porcine small intestinal mucosa/enzymatic hydrolysis method (no salt, papain or mixed enzyme/sodium bisulfite), yield: 2500~ 3500;

China in the 2010s:

(1) Porcine small intestinal mucosa/enzymatic hydrolysis, 1800-1350, occasionally 1200, 2709 enzymes; (2) Porcine small intestine membrane/salt lysis,2200>1500, occasionally 1300;

2010s, Europe and America:

(1) Porcine small intestine station membrane/enzyme hydrolysis method (no salt, papain or mixed enzyme/sodium bisulfite), 3000-2200, occasionally 1800;

(2) The development history of extraction methods and yield improvement of crude heparin sodium